An Ohio killer has been put to death with a type of lethal injection never before tried in a US execution.
Dennis McGuire received the death penalty for the 1989 rape and fatal stabbing of Joy Stewart, a pregnant woman, in Preble County in western Ohio.
State officials used intravenous doses of two drugs, the sedative midazolam and the painkiller hydromorphone, to put McGuire to death.
McGuire appeared to gasp several times during the more than 15 minutes it appeared to take him to die.
It was one of the longest executions since Ohio resumed capital punishment in 1999.
Officials opted for the new lethal injection method after supplies of the state's previous drug dried up.
Prior to the execution, McGuire's lawyers warned that he was at substantial risk of a medical phenomenon known as air hunger, which would cause him to experience terror as he strained to catch his breath.
Ohio officials presented counter evidence disputing the air hunger risk.
Ms Stewart's slaying went unsolved for 10 months until McGuire, jailed on an unrelated assault and hoping to improve his legal situation, told investigators he had information about the woman's death.
His attempts to blame the crime on his brother-in-law quickly unravelled and soon he was accused of being the killer.
More than a decade later, DNA evidence confirmed McGuire's guilt, and he acknowledged that he was responsible in a letter to the state's governor last month.
McGuire, 53, unsuccessfully sought a reprieve in recent weeks to try to become an organ donor, the AP news agency reported.
But he could not identify a family member who would receive his organs, as required under prison policy.
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